Equipment

Characterization

High Performance Liquid Chromatography (HPLC) with Diode Array UV Vis, fluorescence, ELSD, RID detectors for formulation characterization, in vitro release and stability, and polymer molecular weight

Molecular weight determination for polymers, proteins characterization 

Ultraviolet-visible fluorescence plate readers nanodrop for concentration determination, plasma compatibility and solubility screening

Particle Size Determination by Laser Diffraction and Dynamic Light Scattering for micron-sized particles

Osmometer and Viscometer for characterization

Instron Force Tester for force and brake force testing for component compatibility

Scanning Electron Microscope (SEM) for microsphere visualization

MSD ELISA for bioanalysis 

Light Microscopy

Protein Characterization and Purification

Gel Electrophoresis Imager for imaging protein gels

Fast Protein Liquid Chromatography (FPLC) for protein purification

Dynamic light scattering with zeta potential for hydrodynamic radii estimation

Organic synthesis reactors 

Rotary evaporator 

Formulation Process Manufacturing

Laminar Flow-hood for sterile manufacturing and preclinical and stability supply

Dehydrogenation Oven and Autoclave for sterile manufacturing preclinical and stability supply

Extruder for particle size reduction and liposome production

Microfluidizer and Ball Mill for particle size reduction

Filtration Skid for pressured filtration at >1L

Tray Lyophilizer for cycle development

Homogenizer and Probe Sonication for particle size reduction and microsphere production

In vitro release testing for extended-release injectables 

Stability Chambers certified and monitored (ICH conditions 25ºC/60RH, 40ºC/75RH, 2-8ºC, -20ºC, -80ºC)  for evaluation formulation and API stability and container closure evaluation

Jacketed reaction vessels